anticonvulsant activities of 7-phenyl-5h-thiazolo[5,4-e][1,2,3,4]tetrazolo[5,1-c]pyrrolo[1,2-a][1,4]diazepine and 7-phenyl-5h-thiazolo[5,4-e][1,3,4]triazolo[5,1-c] pyrrolo[1,2-a][1,4]diazepines

anticonvulsant activity of 7-phenyl-5h-thiazolo[5,4-e][1,2,3,4]tetrazolo[5,1-c]pyrrolo[1,2-a][1,4]diazepine (5) and 7-phenyl-5h-thiazolo[5,4-e][1,3,4]triazolo[5,1-c]pyrrolo[1,2-a][1,4]diazepines (6a-d) was measured against pentylenetetrazole (ptz)-induced seizures in mice. intraperitoneal injections of different doses (12.5, 25 and 50 mg/kg, i.p.) of test compounds decreased ptz-induced seizure significantly in a dose-dependent manner.the test compounds were administered 30 min befor ptz (80 mg/kg, i.p.) injection. the maximum response was obtained with 50 mg/kg of compound 6d that showed more anticonvulsant activity compared to diazepam (0.5 mg/kg). the frequency of mortality was also decreased by all listed compounds. pretreatment of animals with flumazenile (as a benzodiazepine, bdz receptor antagonist) decreased, but not completely inhibited the anticonvulsant activity of compound 6d (50 mg/kg). these results indicate that besides bzd receptors, other neurotransmitter systems may be involved in anticonvulsant activity of the tested compounds.